過去の放射線増感剤/LAVURCHINに関する論文を紹介しています。併せて下記、未承認薬の提供に関するポリシーもご覧ください。

未承認薬の提供に関するポリシー

株式会社エム・ティー・スリー(以下MT3)は、重篤な疾患に苦しんでいる患者様のために、安全かつ効果的な治療薬の開発に取り組んでいます。MT3は未承認薬が安全かつ効果的であるかどうかを判断するため、責任を持って治験に取り組んでいきます。なお、以下の要件を充たす場合において、MT3は、治験ではないしかるべきプロセスに従って、承認に至っていない未承認薬を提供することを検討いたします。

  • ✓ 重篤な疾患や生命を脅かす疾患の患者様で、代替治療法がない場合
  • ✓ 患者様が治験に参加できない場合、または治療対象として適切でない場合
  • ✓ 当該未承認薬による治療が有益となりうると医師が判断する場合

MT3への未承認薬提供の要請には、それを必要とする主治医の署名入りの書面の提出が必要です。ただし、当該未承認薬の在庫量を含む様々な理由によっては、必ずしもその要請に応じて未承認薬を提供できるとは限りませんことをご了承ください。

発表年 論文タイトル 著者
2018年 A multimodal molecular imaging study evaluates pharmacological alteration of the tumor microenvironment to improve radiation response. American Association for Cancer Research. 2018 Yoichi Takakusagi, Sarwat Naz, Kaori Takakusagi, Masahiro Ishima, Hiroshi Murata, Keisuke Ohta, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Shun Kishimoto, Jeeva P Munasinghe, James B Mitchell and Murali C Krishna
2015年 Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity. Sci. Rep. 2015. J. Izaguirre-Carbonell, H.Kawakubo, H. Murata, A.Tanabe, T. Takeuchi, T.Kusayanagi, S.Tsukuda, T. Hirakawa, K. Iwabata, Y. Kanai, K. Ohta, M. Masahiko, K.Sakaguchi,S. Matsunaga, H. Sahara, S. Kamisuki, and F. Sugawara
2015年 Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model. Mol Ther Oncolytics. 2015. H. Iwamoto,T. Nakamura, H. Koga, J. Izaguirre-Carbonell, S. Kamisuki, F. Sugawara, M. Abe, K. Iwabata,Y. Ikezono, T. Sakaue, A. Masuda,H. Yano, K. Ohta, M. Nakano, S. Shimose, T. Shirono, T.Torimura
2015年 Sulfoquinovosylacylpropanediolis a novel potent radiosensitizer in prostate cancer. Int. J.Urology 2015. Y.Sawada, K. Omoto, N. Kohei, K.Sakaguchi, M. Miura and K. Tanabe
2015年 Increase in tumor oxygenation and radiosensitivity causedby SQAP CG-0321 :Themechanism of actions revealed by in vivo imaging studies. ICRR 15th International Congressof Radiation Research. 2015. 2015.Y.Takakusagi, S. Matsumoto, K. Saito, M. Matsuo, K.Takakusagi,S .Kishimoto, M. Ishima, H. Murata, K. Ohta, M. Miura, F. Sugawara, K.Sakaguchi,J. B .Mitchell, M. C. Krishna
2014年 Identification and study of SQAP-binding proteins from a T7 phage display screen. Planta Medica. 2014. J.Izaguirre-Carbonell, H. Murata, K.Ohta, T. Kusayanagi, S. Tsukuda, K.Iwabata,Y. Kanai, S. Kamisuki,K.Sakaguchi, F. Sugawara
2012年 Anti-angiogenesis effect of 3′-sulfoquinovosyl-1′-monoacylglycerol (SQMG) via upregulation of thrombospondin 1. Cancer Sci. 2012. K.Matsuki, A. Tanabe, F. Sugawara, K.Sakaguchi, N. Takahashi, N.Satoand H. Sahara
2011年 Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1(hnRNPA1) and allosterically inhibits the hnRNP A1/topoisomerase I interaction.Bioorg. Med.Chem. 2011. D. Manita, Y. Toba,Y. Takakusagi, Y. Matsumoto, T.Kusayanagi, K. Takakusagi,K. Takada, Y.Kanai, S. Kamisuki, K. Sakaguchi, F.Sugawara
2010年 Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, a-sulfoquinovosylmonoacylglycerol(a-SQMG), and X-irradiation. Anti Cancer Res. 2010. K. Ohta, H. Murata, Y. Mori, M.Ishima, F. Sugawara, K. Sakaguchi and M. Miura
2008年 Downregulation of Tie2 gene by a novel antitumor sulfolipid,3′-sulfoquinovosyl-1′-monoacylglycerol, targeting angiogenesis. Cancer Sci.2008. Y. Mori, H. Sahara, K.Matsumoto,N. Takahashi, T.Yamazaki, K.Ohta, S. Aoki, M. Miura, F. Sugawara,K. Sakaguchi and N. Sato
2007年 Effects of a new immunosuppressive agent, b-SQAG9, in swine kidney transpalantation.Transplant Immunol. 2007. T. Tanaka, H. Kitamura,H.Sahara, A. Imai, Y. Itoh, I. Honma, E.sato, K.Kobayashi, T. Maeda, M.Takenouchi, K. Ohta, F. Sugawara, K. Sakaguchi, A.Ando, H.Inoko, N.Sato and T. Tsukamoto
2006年 a-Sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. Cancer Res. 2006. I. Sakimoto, K. Ohta, T.Yamazaki, S. Ohtani, H.Sahara, F.Sugawara, K. Sakaguchi and M. Miura
2005年 Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNApolymerase b.FEBSJ. 2005. N. Kasai, Y.Mizushina, H. Murata, T.Yamazaki, T. Ohkubo, K. Sakaguchi and F.Sugawara
2005年 Sulfo-Quinovosyl-Acyl-Glycerol (SQAG), an eukaryotic DNA polymerase inhibitor and anti-cancer agent. Cur. Med.Chem. 2005. Y.Mizushina, N. Kasai, H. Iijima, F. Sugawara, H.Yoshida and K. Sakaguchi
2005年 Inhibition of CD62L (+) T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that bindsto CD62L molecule on the cell surface. Cell Immunol. 2005. Y.Yamamoto,H. Sahara, M. Takenouchi, Y.Matsumoto,A. Imai, T. Fujita, Y. Tamura, N. Takahashi, S.Gasa,K.Matsumoto, K. Ohta, F.Sugawara, K. Sakaguchi, K. Jimbow and N. Sato
2005年 Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug b-SQAG9, which inhibits the response of theCD62L+ T-cell subset. Transplant Proc. 2005. M.Takenouchi, H. Sahara,Y. Yamamoto, Y. Matsumoto, A. Imai, T.Fujita, Y. Tamura, N.Takahashi,S. Gasa, K. Matsumoto, K. Ohta, F. Sugawara,K. Sakaguchi, K. Jimbowand N. Sato
2005年 Mammalian mitotic centromere-associated kinesin (MCAK), a newmolecular target of sulfoquinovosylacylglycerols (SQAGs), novel anti-tumor and immunosuppressive agents.FEBS Journal. 2005. S. Aoki, K.Ohta, T. Yamazaki, F. Sugawara and K. Sakaguchi
2004年 Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injuryin rats. Transplant Proc. 2004. T. Tsuruma, H.Sahara, M. Takenouchi, A.Yagihashi, Y. Iwayama, H. Shima, T. Furuhata T,Torigoe, S.Hanashima,T. Yamazaki, F. Sugawara, Y. Mizushina, K. Ohta, K,Sakaguchi, N. Satoand K.Hirata
2004年 Synthesis of an immunosuppressant SQAG9 and determination of thebinding peptidebyT7 phage display. Bioorg. Med. Chem. Lett. 2004. T.Yamazaki, S. Aoki, K. Ohta, S. Hyuma,K.Sakaguchi and F. Sugawara
2004年 Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-unsaturated fatty acid (C18-SQMG). Biochem. Pharmacol.2004. C.Murakami, T. Miuzno, F.Hanaoka, H. Yoshida, K. Sakaguchi andY. Mizushina
2003年 The inhibitory action of emulsified sulfoquinovosyl acylglycerol on the mammalian DNA polymerases. Lipids.2003 Y.Mizushina, N.Maeda, M.Kawasaki, H.Ichikawa, C.Murakami, M.Takemura, X.Xu, F.Sugawara, Y.Fukumori, H.Yoshida and K.Sakaguchi
2003年 Analysis of cell cycle regulation by1-mono-O-acyl-3-O-(a-D-sulfoquinovosyl)-glyceride(SQMG), an inhibitor of eukaryotic DNA polymerases. Biochem. Pharmacol. 2003. C.Murakami, M. Takemura,H.Yoshida, F. Sugawara, K. Sakaguchi and Y. Mizushina
2003年 A sulfoquinovosyl diacylglycerol is a DNA polymerase e inhibitor.Biochem. J. 2003. Y.Mizushina, X. Xu, H.Asahara, R. Takeuchi, M.Oshige, N. Shimazaki, M. Takemura, T,Yamaguchi, K.Kuroda, S. Linn, H.Yoshida, O. Koiwai, M. Saneyoshi, F. Sugawara and K.Sakaguchi
2002年 An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin. Transplantation. 2002. Y.Matsumoto, H. Sahara, T.Fujita, K.Shimozawa, M. Takenouchi, T.Torigoe, S. Hanashima, T. Yamazaki, S.Takahashi, F.Sugawara, Y.Mizushina, K. Ohta, N. Takahashi, S. Gasa, K.Jimbow, K. Sakaguchi, N.Sato
2002年 Structure-activity relationship of synthetic sulfoquinovosylacylglycerols as a mammalian DNA polymerases inhibitor.Arch.Biochem. Biophys. 2002. C. Murakami, T. Yamazaki, S.Hanashima,S. Takahashi,K. Ohta, H. Yoshida, F. Sugawara, K. Sakaguchi and Y.Mizushina
2002年 Anti-tumor effect of chemically synthesized sulfolipids deduces from sea urichin’s natural sulfonoquinovosylmonoacyl glycerols. Jpn. J. CancerRes. 2002. H. Sahara, S. Hanashima, T.Yamazaki, S. Takahashi,F.Sugawara, S. Ohtani, M. Ishikawa, Y. Mizushina, K. Ohta, N.Takahashi,S.Gasa, M. Mori, K. Sakaguchi and N. Sato
2001年 Specific interaction between oligosaccharide on tumor cell surface and novel antitumor agents, sulfoquinovosylmonoacylglycerols. Biochem.Biophys. Res. Comm. 2001. K. Ohta,Y.Mizushina, T. Yamazaki, S.Hanashima, F. Sugawara and K.Sakaguchi
2001年 Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase a and b. Bioorg. Med. Chem. 2001. S. Hanashima, Y.Mizushina, T. Yamazaki, K. Ohta, S.Takahashi,H. Sahara, K. Sakaguchiand F.Sugawara
2000年 A novel immunosuppressive agent, SQDG, derived from sea urchin.Transplant Proc.2000. Y. Matsumoto, H. Sahara, T. Fujita,S. Hanashima,T. Yamazaki, S. Takahashi, F. Sugawara, Y.Mizushina, K. Ohta, N.Takahashi, K. Jimbow, K. Sakaguchi and N. Sato
2000年 Structure-activity relationship of a novel inhibitor group of mammalian DNA polymerases,synthetic sulfoquinovosylacylglycerols. Jpn. J.CancerRes. 2000. S. Hanashima, Y. Mizushina,K. Ohta, T. Yamazaki, F.Sugawaraand K. Sakaguchi
2000年 Structural determination of sulfoquinovosyldiacylglycerol by chiral synthesis.TetrahedronLetters. 2000. S.Hanashima, Y. Mizushina, T.Yamazaki, K. Ohta, S. Takahashi,H. KOshino, H.Sahara, K. Sakaguchiand F. Sugawara
2000年 Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: Inhibitory action on cell proliferation. Mutat.Res. 2000. K. Ohta,S. Hanashima, Y. Mizushina,T. Yamazaki, M.Saneyoshi, F. Sugawara and K. Sakaguchi
1999年 Inhibitory effect of mixed lymphocyte reaction by synthetic sulfolipids which are stereoisomers of sulfonoquinovosyldiacylglycerol derived froms ea urchin. Bulletin of the Marine Biomedical Institute, Sapporo MedicalUniversity School of Medicine. 1999. Y.Matsumoto, H. Sahara, T. Fujita,S.Hanashima, T. Yamazaki, S. Takahashi, Y.Mizushina, K.Ohta, F.Sugawara, K.Sakaguchi, M. Mori, S. Gasa, K. Jimbow, N. Takahashi andH. Sato
1999年 Approach of chemical biology: A case study on sulfolipids. From findings of natural products, structural determinations, chemical syntheses and pharmaceutical potentials to future therapeutic usage as a goal. Bulletin of the Marine Biomedical Institute,SapporoMedicalUniversity School of Medicine. 1999. F. Sugawara, S. Hanashima,Y.Mizushina,T.Yamazaki, K. Ohta, M. Okada, T. Yamagata K. Sakaguchi, S.Takahashi, H. Koshino and H.Sato
1999年 Studies on action of sulfoquinovosyldiacylglycerol, a new mammalian DNA polymerase inhibitor, from a sea alga,Gigartina tenella. Biol. Pharm.Bull. 1999. K. Ohta, Y. Mizushina,N.Hirata, M. Takemura, F. Sugawara,A. Matsukage, S. Yoshida and K. Sakaguchi
1998年 Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase 1 from a marine red alga,Gigartina tennella. Chem.Pharm. Bull. 1998. K. Ohta, Y.Mizushina, N.Hirata, M. Takemura, F. Sugawara, A.Matsukage, S.Yoshida and K. Sakaguchi
1997年 AIDS-antiviral sulfolipids from a pteridophyta, athyrium niponicum, are selective inhibitors of mammalian DNA polymerase a and b, but not of HIV reverse transcriptase.Biochem.Pharmacol. 1997. Y. Mizushina, I.Watanabe, K. Ohta, M. Takemura, H. Sahara, F.Sugawara,A.Matsukage, S.Yoshida and K. Sakaguchi
1997年 In vivo anti-tumour effect of 3′.sulphonoquinovosyl 1′-monoacylglyceride isolated from sea urchin (Strongylocentrotusintermedius) intestine. British Joumal of Cancer. 1997. HSahara, MIshikawa, N Takahashi, S Ohtani, N Sato, S Gasa, TAkino and K Kikuchi
1996年 Screening of inhibitor of eukaryotic DNA polymerases produced by microorganisms. J.Antibiot. 1996. Y. Mizushina, H. Yagi, N. Tanaka, T.Kurosawa, H. Seto, K. Katsumi, M.Onoue,H. Ishida, A. Iseki, T. Nara, K.Morohashi,T. Horie, Y.Onomura, M. Narusawa, N.Aoyagi, K.Takami, M.Yamaoka, Y. Inoue, A. Matsukage,S. Yoshida and K. Sakaguchi