The following are R&D reports with regard to the radiosensitizer, LAVURCHIN.

Year Title Author
2020 The Outcome and CT Findings of Low-Dose Intensity Modulated Radiation Therapy with SQAP in a Cat with Thymoma / Vet Sci. 2020 Dec 14;7(4):E203 Kutara K, Mochizuki Y, Ohnishi A, Mitsui I, Kanda T, Sugiyama A, Maeta N, Kobayashi K, Shimizu Y, Okamura Y, Asanuma T.
2019 Distribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice. / Xenobiotica. 2019 Mar;49(3):346-362. Ruike T, Kanai Y, Iwabata K, Matsumoto Y, Murata H, Ishima M, Ohta K, Oshige M, Katsura S, Kuramochi K, Kamisuki S, Sahara H, Miura M, Sugawara F, Sakaguchi K.
2018 A multimodal molecular imaging study evaluates pharmacological alteration of the tumor microenvironment to improve radiation response. / Cancer Res. 2018 Dec 15;78(24):6828-6837. Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.
2015 Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model. / Mol Ther Oncolytics. 2015 Dec 2;2:15020. Iwamoto H, Nakamura T, Koga H, Izaguirre-Carbonell J, Kamisuki S, Sugawara F, Abe M, Iwabata K, Ikezono Y, Sakaue T, Masuda A, Yano H, Ohta K, Nakano M, Shimose S, Shirono T, Torimura T.
2015 Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity. / Sci Rep. 2015 Oct 12;5:15136. doi: 10.1038/srep15136. Izaguirre-Carbonell J, Kawakubo H, Murata H, Tanabe A, Takeuchi T, Kusayanagi T, Tsukuda S, Hirakawa T, Iwabata K, Kanai Y, Ohta K, Miura M, Sakaguchi K, Matsunaga S, Sahara H, Kamisuki S, Sugawara F.
2015 Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer. / Int J Urol. 2015 Jun;22(6):590-5. Sawada Y, Omoto K, Kohei N, Sakaguchi K, Miura M, Tanabe K.
2014 Identification and study of SQAP-binding proteins from a T7 phage display screen / Planta Medica. 2014;80(10) Izaguirre-Carbonell J, Murata H, Ohta K, Kusayanagi T, Tsukuda S, Iwabata K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F.
2012 Anti-angiogenesis effect of 3′-sulfoquinovosyl-1′-monoacylglycerol via upregulation of thrombospondin 1. / Cancer Sci. 2012 Aug;103(8):1546-52. Matsuki K, Tanabe A, Hongo A, Sugawara F, Sakaguchi K, Takahashi N, Sato N, Sahara H.
2011 Binding region and interaction properties of sulfoquinovosylacylglycerol (SQAG) with human vascular endothelial growth factor 165 revealed by biosensor-based assays / Med. Chem. Commun. 2011;2:1188-1193 Takakusagi Y, Takakusagi K, Ida N, Takami M, Matsumoto Y, Kusayanagi T, Nakabayashi T, Aoki S, Murata H, Ohta K, Sugawara F, Sakaguchi K.
2010 Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, {alpha}-sulfoquinovosylmonoacylglycerol ({alpha}-SQMG) and X-irradiation. / Anticancer Res. 2010 Nov;30(11):4397-404. Ohta K, Murata H, Mori Y, Ishima M, Sugawara F, Sakaguchi K, Miura M.
2008 Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3′-sulfoquinovosyl-1′-monoacylglycerol, targeting angiogenesis. / Cancer Sci. 2008 May;99(5):1063-70. Mori Y, Sahara H, Matsumoto K, Takahashi N, Yamazaki T, Ohta K, Aoki S, Miura M, Sugawara F, Sakaguchi K, Sato N.
2007 Protective mechanism of beta-SQAG9 liposome, a sulfonoglycolipid extracted from sea urchin intestines, against hepatic ischemia reperfusion injury / Shock. 2007 Jul;28(1):94-100. Shima H, Tsuruma T, Sahara H, Takenouchi M, Takahashi N, Iwayama Y, Yagihashi A, Watanabe N, Sato N, Hirata K.
2007 Effects of a new immunosuppressive agent, beta-SQAG9, in swine kidney transplantation. / Transpl Immunol. 2007 Jul;18(1):67-71. Tanaka T, Kitamura H, Sahara H, Imai A, Itoh Y, Honma I, Sato E, Kobayashi K, Maeda T, Takenouchi M, Ohta K, Sugawara F, Sakaguchi K, Ando A, Inoko H, Sato N, Tsukamoto T.
2007 Sulfoglycolipids as candidate antiangiogenic radiosensitizers / Anticancer Drugs. 2007 Jan;18(1):1-5. Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K.
2006 An emulsion of sulfoquinovosylacylglycerol with long-chain alkanes increases its permeability to tumor cells / J Membr Biol. 2006;213(1):11-8. Aoki S, Ohta K, Matsumoto K, Sakai H, Abe M, Miura M, Sugawara F, Sakaguchi K.
2006 Alpha-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. / Cancer Res. 2006 Feb 15;66(4):2287-95. Sakimoto I, Ohta K, Yamazaki T, Ohtani S, Sahara H, Sugawara F, Sakaguchi K, Miura M.
2005 Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent. / Curr Med Chem Anticancer Agents. 2005 Nov;5(6):613-25 Mizushina Y, Kasai N, Iijima H, Sugawara F, Yoshida H, Sakaguchi K.
2005 Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta. / FEBS J. 2005 Sep;272(17):4349-61. Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F.
2005 Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents. / FEBS J. 2005 May;272(9):2132-40. Aoki S, Ohta K, Yamazaki T, Sugawara F, Sakaguchi K.
2005 Treatment with beta-SQAG9 prevents rat hepatic ischemia-reperfusion injury / Transplant Proc. Jan-Feb 2005;37(1):417-21. Shima H, Tsuruma T, Sahara H, Takenouchi M, Takahashi N, Iwayama Y, Yagihashi A, Watanabe N, Sato N, Hirata K.
2005 Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug beta-SQAG9, which inhibits the response of the CD62L+ T-cell subset. / Transplant Proc. 2005 Jan-Feb;37(1):139-42. Takenouchi M, Sahara H, Yamamoto Y, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N.
2004 Design of vesicles of 1,2-di-O-acyl-3-O-(beta-D-sulfoquinovosyl)-glyceride bearing two stearic acids (beta-SQDG-C18), a novel immunosuppressive drug / Biochem Pharmacol. 2004 Dec 15;68(12):2379-86. Matsumoto K, Takenouchi M, Ohta K, Ohta Y, Imura T, Oshige M, Yamamoto Y, Sahara H, Sakai H, Abe M, Sugawara F, Sato N, Sakaguchi K.
2004 Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that binds to CD62L molecule on the cell surface. / Cell Immunol. 2004 Nov-Dec;232(1-2):105-15. Yamamoto Y, Sahara H, Takenouchi M, Matsumoto Y, Imai A, Fujita T, Tamura Y, Takahashi N, Gasa S, Matsumoto K, Ohta K, Sugawara F, Sakaguchi K, Jimbow K, Sato N.
2004 Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. / Transplant Proc. 2004 Sep;36(7):1965-9. Tsuruma T, Sahara H, Takenouchi M, Yagihashi A, Iwayama Y, Shima H, Furuhata T, Torigoe T, Hanashima S, Yamazaki T, Sugawara F, Mizushina Y, Ohta K, Sakaguchi K, Sato N, Hirata K.
2004 Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display. / Bioorg Med Chem Lett. 2004 Aug 16;14(16):4343-6. Yamazaki T, Aoki S, Ohta K, Hyuma S, Sakaguchi K, Sugawara F.
2004 Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-saturated fatty acid (C18-SQMG). / Biochem Pharmacol. 2004 Apr 1;67(7):1373-80. Murakami C, Miuzno T, Hanaoka F, Yoshida H, Sakaguchi K, Mizushina Y.
2003 Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases. / Lipids. 2003 Oct;38(10):1065-74. Mizushina Y, Maeda N, Kawasaki M, Ichikawa H, Murakami C, Takemura M, Xu X, Sugawara F, Fukumori Y, Yoshida H, Sakaguchi K.
2003 Analysis of cell cycle regulation by 1-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride (SQMG), an inhibitor of eukaryotic DNA polymerases. / Biochem Pharmacol. 2003 Aug 15;66(4):541-50. Murakami C, Takemura M, Yoshida H, Sugawara F, Sakaguchi K, Mizushina Y.
2003 A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor. / Biochem J. 2003 Feb 15;370(Pt 1):299-305. Mizushina Y, Xu X, Asahara H, Takeuchi R, Oshige M, Shimazaki N, Takemura M, Yamaguchi T, Kuroda K, Linn S, Yoshida H, Koiwai O, Saneyoshi M, Sugawara F, Sakaguchi K.
2003 A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid / Biochim Biophys Acta. 2003 Jan 31;1645(1):72-80. Murakami C, Yamazaki T, Hanashima S, Takahashi S, Takemura M, Yoshida S, Ohta K, Yoshida H, Sugawara F, Sakaguchi K, Mizushina Y.
2002 An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin. / Transplantation. 2002 Jul 27;74(2):261-7. Matsumoto Y, Sahara H, Fujita T, Shimozawa K, Takenouchi M, Torigoe T, Hanashima S, Yamazaki T, Takahashi S, Sugawara F, Mizushina Y, Ohta K, Takahashi N, Gasa S, Jimbow K, Sakaguchi K, Sato N.
2002 Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors. / Arch Biochem Biophys. 2002 Jul 15;403(2):229-36. Murakami C, Yamazaki T, Hanashima S, Takahashi S, Ohta K, Yoshida H, Sugawara F, Sakaguchi K, Mizushina Y.
2002 Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin’s natural sulfonoquinovosylmonoacylglycerols. / Jpn J Cancer Res. 2002 Jan;93(1):85-92. Sahara H, Hanashima S, Yamazaki T, Takahashi S, Sugawara F, Ohtani S, Ishikawa M, Mizushina Y, Ohta K, Shimozawa K, Gasa S, Jimbow K, Sakaguchi K, Sato N, Takahashi N.
2001 Specific interaction between an oligosaccharide on the tumor cell surface and the novel antitumor agents, sulfoquinovosylacylglycerols. / Biochem Biophys Res Commun. 2001 Nov 9;288(4):893-900. Ohta K, Mizushina Y, Yamazaki T, Hanashima S, Sugawara F, Sakaguchi K.
2000 A novel immunosuppressive agent, SQDG, derived from sea urchin. / Transplant Proc. 2000 Nov;32(7):2051-3. Matsumoto Y, Sahara H, Fujita T, Hanashima S, Yamazaki T, Takahashi S, Sugawara F, Mizushina Y, Ohta K, Takahashi N, Jimbow K, Sakaguchi K, Sato N.
2000 Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols. / Jpn J Cancer Res. 2000 Oct;91(10):1073-83. Hanashima S, Mizushina Y, Ohta K, Yamazaki T, Sugawara F, Sakaguchi K.
2000 Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: inhibitory action on cell proliferation. / Mutat Res. 2000 May 8;467(2):139-52. Ohta K, Hanashima S, Mizushina Y, Yamazaki T, Saneyoshi M, Sugawara F, Sakaguchi K.
1999 Action of a new mammalian DNA polymerase inhibitor, sulfoquinovosyldiacylglycerol. / Biol Pharm Bull. 1999 Feb;22(2):111-6. Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K.
1998 Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella. / Chem Pharm Bull (Tokyo). 1998 Apr;46(4):684-6. Ohta K, Mizushina Y, Hirata N, Takemura M, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K.
1998 Studies on inhibitors of mammalian DNA polymerase alpha and beta: sulfolipids from a pteridophyte, Athyrium niponicum / Biochem Pharmacol. 1998 Feb 15;55(4):537-41. Mizushina Y, Watanabe I, Ohta K, Takemura M, Sahara H, Takahashi N, Gasa S, Sugawara F, Matsukage A, Yoshida S, Sakaguchi K.
1997 In vivo anti-tumour effect of 3′-sulphonoquinovosyl 1′-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine. / Br J Cancer. 1997;75(3):324-32. Sahara H, Ishikawa M, Takahashi N, Ohtani S, Sato N, Gasa S, Akino T, Kikuchi K.