Combination Therapy of LAVURCHIN & Radiotherapy

  • What kind of treatment is the combination therapy of LAVURCHIN & radiotherapy?

    It is a cancer treatment method that uses LAVURCHIN (drug), having a radiosensitizing effect, in combination with conventional radiotherapy

  • What is the difference between the combination therapy and conventional radiotherapy?

    Radiotherapy is a treatment employing radiation to damage and destroy cancer tissue by irradiating the cancer tissue with radiation. For the radiation to damage the cancer tissue, there is a need for oxygen to be present in the cancer tissue. However, cancer tissues usually have a subnormal concentration of oxygen (i.e., a hypoxic state). LAVURCHIN that has a radiosensitizing effect temporarily creates a state in which there is an excessive amount of oxygen (i.e., a hyperoxic state) in the cancer tissue. Thus, by using LAVURCHIN in combination with radiotherapy, we can increase damage to the cancer tissue without increasing the dose of radiation.

  • How long is the treatment period?

    The conventional treatment period of radiotherapy varies depending on the type of cancer. Irradiation is on average 6 to 12 times over a treatment period of 2 to 4 weeks. With the use of LAVURCHIN, there is a possibility of reducing the treatment period and the number of times of irradiation.

  • Is hospitalization required?

    The combination therapy can be conducted in an inpatient or outpatient arrangement. However, this is jurisdiction of the institution that is conducting the treatment and the arrangement is determined by the institution according to it’s treatment policy.

  • Is there discomfort or pain that accompanies irradiation?

    There is neither pain nor discomfort, such as a feeling of heat, that accompanies irradiation. In cases of radiotherapy for patients of dogs and cats, general anesthesia is applied for the purpose of preventing movement of patients during irradiation.

  • How is LAVURCHIN used in combination with radiotherapy?

    After general anesthesia, LAVURCHIN is administered to the entire body via intravenous injection. Irradiation is executed on cancer tissue after the administration of LAVURCHIN.

  • Are there any side effects (Adverse reactions with respect to treatment)?

    At present, around 100 patients have participated in clinical trials of LAVURCHIN for veterinary use. No serious adverse reaction of a life-threatening level have been confirmed to be correlated with LAVURCHIN. Also, there are no cases of allergic reactions.
    There are reports of vasculitis occurring at the site of injection caused by administration via intravenous injection. However, this occurrence does not apply to all patients.
    Symptoms such as hair loss, fatigue, vomiting and the like accorded to normal levels of irradiation in radiotherapy may occur.

  • Are there any adverse effects on healthy tissues by using LAVURCHIN (radiosensitizer)?

    When intravenously injected into the body, LAVURCHIN reacts only with cancer tissue and induces a hyperoxic state in the cancer tissue. In healthy tissue, LAVURCHIN is absorbed and metabolized and no reaction takes place.
    There is no danger of healthy tissues being exposed to an increased amount of X-ray irradiation that is beyond the normal parameters of radiotherapy with the combinational use of LAVURCHIN.

  • Will the patient be able to continue with daily activities such as take meals and take walks during treatment?

    In most circumstances, daily activities are not hampered. However, depending on the site that needs treatment and the condition of the disease, there may be side effects that may influence daily activities.

  • Is the combination therapy of LAVURCHIN & radiotherapy applicable to sites that have been treated with radiotherapy in the past?

    Various factors such as past dose of radiation and the like need to be carefully considered for treatment of a site that has been treated with radiotherapy in the past. This is a decision that is determined by the involved veterinary specialists.

  • How can I receive the combination therapy of LAVURCHIN & radiotherapy?

    Please contact us via the inquiry form.
    At present, clinical trials of LAVURCHIN for veterinary use & radiotherapy are in progress.
    Clinical trials with respect to achieving a status of medicinal product for human use will be conducted in the future. Latest information on our activities and progress will be disclosed on the HP. Please refer to the Newsroom section.

  • How much will the combination therapy cost?

    The cost will vary depending upon the type of cancer and the number of times irradiation is conducted. Please directly ask the veterinary hospital conducting the combination therapy.